ABOUT MOAB

DEVELOPED BY SCIENTISTS,
MADE FOR THE INDUSTRY

MOAB was incorporated in 2019 as a spin-off of Politecnico di Milano. The company traces its roots to the laboratory of Prof. Manuela T. Raimondi, awarded with three European Research Council grants.

As a results of 10 years of development in nanoengineered stem cells niches, microfluidic bioreactors, and miniaturized windows for imaging in live animals, MOAB is now an industrial product.

Since 2019 MOAB has been used by several customers with different goals in a large variety of scientific fields, from neural cells to lymph nodes, from regenerative medicine to gene editing.

MEET THE TEAM

MILESTONESThe history of MOAB

2011

MOAB V.1

Prototype made in glass, one magnetic lid for three chambers

– Expensive production process (CNC milling of glass slide) not suitable for large manufacturing

– Fluidic interface using stainless steel needle connectors

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2014

MOAB V.2

First evolution with three independent chambers and separated magnetic lids

– 3D SLA Printing for chambers and lids

– Fluidic interface using stainless steel needle connectors

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2016

MOAB V.3

Patented Design optimized for mass production criteria

– Affordable injection moulding process

– Fluidic interface using silicone tubing and LuerLocks connections

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2019

Foundation of the company MOAB S.r.l.

– Partnership of experienced entrepreneur together with scientific and industrial partners

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2020

MOAB won and completed the Phase 1 of CRACK IT challenge

– 6 months grant for the research project: “Development of an in vitro viability and tumorigenicity index for genome-edited hHSCs with the MOAB bioreactor.”

– Challenge promoted by the NC3Rs
(National Centre for the Replacement Refinement & Reduction of Animals in Research)

– Challenge sponsored by Bayer, Novartis and Takeda

– Scientific contributions:

- Dr. Raimondi lab – Polytechnic University of Milano
- Dr. Balduini Lab – University of Pavia
- Dr. Brendolan Lab – IRCCS San Raffaele Scientific Institute
- Dr. Di Micco Lab – The San Raffaele Telethon Institute for Gene Therapy
- Dr. Biffo Lab from – University of Milano

CRACK IT – Visit Page

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2021

MOAB won The CRACK IT challenge – Phase 2 (on-going)

– 3 years grant for the prosecution of the project: “Development of an in vitro viability and tumorigenicity index for genome-edited hHSPCs with the MOAB bioreactor”

– Challenge promoted by NC3Rs and sponsored by Bayer, Novartis and Takeda

– Scientific contributions:

- Dr. Raimondi lab – Polytechnic University of Milano
- Dr. Balduini Lab – University of Pavia
- Dr. Brendolan Lab – IRCCS San Raffaele Scientific Institute
- Dr. Di Micco Lab – The San Raffaele Telethon Institute for Gene Therapy
- Dr. Biffo Lab from – University of Milano

CRACK IT – Visit Page

MOAB V.3.1

Design optimized for long term perfusion experiments (t > 1 month)

– Design optimization of magnetic lids and fluidic interface

– Approach focused on continuous improvement based on the feedback from the users

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MOABBROCHURE

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